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Darbepoetin Alfa, with a half-life of about 25 hours.

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You may need to eat foods that contain iron, folic acid, or vitamin B12 such as eggs, certain cereals, meats, and vegetables, or you may take an iron, folic acid, or vitamin B12 supplement while you are using this medicine.

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Review signs and symptoms of digitalis toxicity with patient and family.

Larger, double-blind, placebo-controlled studies as well as studies evaluating alternative criteria for the use of epoetin alfa are warranted to further assess the effects of epoetin alfa on HRQOL, maintenance of RBV dose, and HCV response.

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The first evidence of a response to the three times weekly (TIW) administration of epoetin alfa is an increase in the reticulocyte count within 10 days, followed by increases in the red cell count, hemoglobin, and hematocrit, usually within 2 to 6 weeks.

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Erythropoietin (EPO), a hormone necessary for red blood cell production in bone marrow, is produced by peritubular cells in the kidney in response to hypoxia.

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Darbepoetin alfa safety and efficacy have not been established in the initial treatment of anemic pediatric patients with CKD or in the transition from another erythropoietin to darbepoetin alfa in pediatric CKD patients less than 1 year of age.

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Because the only definitive causal mechanism demonstrated through research to date is chemotherapy-induced anemia, most clinical recommendations for managing fatigue caused by something other than chemotherapy-induced anemia rely on careful development of clinical hypotheses, as outlined in the National Comprehensive Cancer Network guidelines on fatigue.

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