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Larger, double-blind, placebo-controlled studies as well as studies evaluating alternative criteria for the use of epoetin alfa are warranted to further assess the effects of epoetin alfa on HRQOL, maintenance of RBV dose, and HCV response.
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Figure 1 Association between Hemoglobin Level and Dose of Darbepoetin Alfa, According to the Level of Response to the First Two Doses.
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Erythropoietin response to anaemia is not altered by surgery or recombinant human erythropoietin therapy.
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Use and dose must be determined by your doctor.
Because the only definitive causal mechanism demonstrated through research to date is chemotherapy-induced anemia, most clinical recommendations for managing fatigue caused by something other than chemotherapy-induced anemia rely on careful development of clinical hypotheses, as outlined in the National Comprehensive Cancer Network guidelines on fatigue.
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