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Several diagnostic strategies using ultrasound imaging, measurement of D-dimer, and assessment of clinical probability of disease have proved safe in patients with suspected deep-vein thrombosis, but they have not been compared in randomized trials.

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Participants Non-pregnant Danish women aged 15-49 with no history of thrombotic disease and followed from January 2001 to December 2009.

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Hormone therapy for preventing cardiovascular disease in post-menopausal women".

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The follow-up period was also relatively short (maximum of two years and three months), which limits the bias associated with changing diagnostic procedures and health system management of the three events of interest, and eliminated the potential time trend bias.

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