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Figure 3 presents the proportion of patients (X axis) whose percentage reduction from baseline in complex partial seizure rates was at least as great as that indicated on the Y axis in the monotherapy study.
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Mania, which is the most common target of mood stabilizers, lasts much longer than a seizure, but there may be some similar types of instability in the neurons of the brain shared by seizures and mania.
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On July 10, 2008, an advisory panel was convened by the Food and Drug Administration (FDA) to review data that the FDA had previously collected from drug studies showing an association between many of the antiepileptic drugs (AEDs) and suicidal ideation and behavior, which together are called suicidality.
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FDA first approved Depakene (valproic acid) in 1978 for the treatment of epilepsy.
Valproic acid may produce teratogenic effects in the offspring of women receiving the drug during pregnancy, Thrombocytopenia, an abnormally low number of platelets in the blood, has also been associated with Depakote use.
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Data from the North American Antiepileptic Drug (NAAED) Pregnancy Registry found that the risk of giving birth to a child with a neural tube defect was 1-in-20 for women who took valproate during the first 12 weeks of pregnancy.
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The American Academy of Neurology has recommended avoiding valproic acid in pregnancy, if possible, on the basis of evidence that exposure to valproic acid is associated with an increased risk of major congenital malformations and poor cognitive outcomes and confers a higher risk than that associated with exposure to other antiepileptic drugs.
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To minimize the risk of misclassification, we excluded all registrations for which there had been a previous diagnosis of maternal epilepsy but for which there was no history of maternal antiepileptic-drug use in the first trimester (a total of 96 cases, 122 controls in group 1, and 19 controls in group 2).
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Take your doses at regular intervals.
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Nor is it a substitute for seeking appropriate medical, or other professional advice.
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Keppra does have some track record of being effective in treating JME (from what I've read), but of course your results may vary.
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