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Efforts such as the extensive transcriptional profiling of human cell lineage differentiation must be extended for a more comprehensive picture of human immunity, which will help us better understand how the ImmGen data will translate across species.
The disease may be chronic and cyclic with spontaneous remissions and recurrences.
Studies suggesting that step-up csDMARD combination therapy was as effective as a step-up combination of a biological agent with MTX were seen to be in conflict with results from other studies showing better efficacy of addition of a bDMARD.
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