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THURSDAY, June 20, 2002 HealthDayNews A European study pushes a new kind of drug closer to replacing the old standard, tamoxifen, in preventing the return of breast cancer after surgery.

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Treatment focuses not only on survival, but on symptom relief and quality of life issues.

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The Level of Evidence (LOE) is an estimate of the certainty or precision of the treatment effect.

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If systolic dysfunction is present, regional wall motion abnormalities or LV aneurysm suggest an ischemic basis for heart failure, whereas global dysfunction suggests a nonischemic cause.

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Fortunately, long-term data on carvedilol have recently become available from a trial of 415 patients with mild-to-moderate heart failure due to ischemic heart disease who were treated for 18 to 24 months.

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Echocardiography is helpful in determining other causes, such as valvular heart disease, cardiac tamponade, or pericardial constriction, and provides useful clues about infiltrative and restrictive cardiomyopathies.

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